Targeting the extracellular matrix: Matricellular proteins regulate cell–extracellular matrix communication within distinct niches of the intervertebral disc
نویسندگان
چکیده
منابع مشابه
determinant of the hankel matrix with binomial entries
abstract in this thesis at first we comput the determinant of hankel matrix with enteries a_k (x)=?_(m=0)^k??((2k+2-m)¦(k-m)) x^m ? by using a new operator, ? and by writing and solving differential equation of order two at points x=2 and x=-2 . also we show that this determinant under k-binomial transformation is invariant.
15 صفحه اولIntegrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin (LM) isoforms LM-111 and LM-511 through select integrins that regulate biosynthesis and cell attachment. Since human NP cells lose many phenotypic characteristics with age...
متن کاملExtracellular matrix remodeling in experimental intervertebral disc degeneration
OBJECTIVE To evaluate the remodeling of the extracellular matrix in intervertebral disc degeneration through the experimental model of intervertebral disc degeneration. METHODS The model of disc degeneration induction, using needle 20G and 360° rotation, was applied for 30 seconds between the 6(th)/7(th), and 8(th)/9(th) coccygeal vertebrae of Wistar rats. The intermediary level, between the ...
متن کاملDegenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins.
Degeneration of intervertebral discs (IVDs) is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose the avascular nucleus pulposus (NP) to the systemic circulation and induce an autoimmune reaction. In this study, we confirmed our previous obs...
متن کاملQuantification of Extracellular Matrix Proteins in the Nucleus Pulposus and Anulus Fibrosus of the Human Intervertebral Disc: Variation with Aging
*Singh, K; *Masuda, K; *Thonar, E.; *An, H; +*Cs-Szabo, G +* Rush University Medical Center, Chicago, IL [email protected] INTRODUCTION: The functions of the intervertebral disc (IVD) as a unit, and of the annulus fibrosus (AF) and nucleus pulposus (NP) individually, are determined by the molecular composition of their extracellular matrices (ECM). The outerand inner-AF consists of large collag...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2014
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2014.05.005